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  • Title: Velocity of axonal transport of phospholipid in rat sciatic nerve.
    Author: Guy JR, Bisby MA.
    Journal: Exp Neurol; 1983 Dec; 82(3):706-10. PubMed ID: 6197318.
    Abstract:
    The difficulties involved in measuring axonal transport velocity for phospholipid in mammalian axons have been overcome by using a reversible local cold-block technique which causes a local accumulation of labeled phospholipid in rat sciatic nerve that follows injection of [methyl 3H]choline chloride into the L5 dorsal root ganglion. On rewarming the nerve a distinct front of [3H]-activity moves distally from the cold-block site at 17.8 mm X h-1, a velocity not significantly different from that previously determined for protein. This observation provides further support for the hypothesis that fast axonal transport conveys membranes assembled in the cell body.
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