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  • Title: A morphologic and histochemical study of metaplastic polyps of the colorectum.
    Author: Jass JR, Filipe MI, Abbas S, Falcon CA, Wilson Y, Lovell D.
    Journal: Cancer; 1984 Feb 01; 53(3):510-5. PubMed ID: 6198059.
    Abstract:
    A combined morphologic and histochemical study of metaplastic polyps of the colorectum was undertaken. With increasing size, these lesions showed alterations in architecture and differentiation, increased secretion of carcinoembryonic antigen and a reduced secretion of O-acylated sialomucin. These functional changes are also observed in colorectal cancers, but not in tubular adenomas showing low-grade dysplasia. Since there is little clinical evidence for a metaplastic polyp-carcinoma sequence, it is suggested that the sets of factors which lead to adenoma and metaplastic polyp formation in the colorectum are both required to induce malignant transformation.
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