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  • Title: Acute effects of mitoxantrone on the template activity of isolated nuclei from the T-47D human breast tumor cell line.
    Author: Chegini N, Safa AR, Tseng MT.
    Journal: Cancer Lett; 1984 Jan; 21(3):329-36. PubMed ID: 6198072.
    Abstract:
    The effect of mitoxantrone on the template activity of nuclei isolated from the T-47D human breast tumor cell line was investigated. The results suggest that mitoxantrone significantly inhibits total RNA synthesis of these nuclei in a concentration-dependent manner. At low drug concentrations (10(-9) M and 10(-7) M) RNA synthesis was inhibited by 21.9% and 41% compared to control values, respectively. Greater inhibition was observed when the mitoxantrone concentration was increased to 10(-5) M or 10(-4) M (56% and 77%, respectively). Experiments utilizing alpha-amanitin revealed that mitoxantrone inhibits RNA polymerase II activity in a concentration-dependent manner.
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