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  • Title: Changes in the pattern reversal visual evoked potential as a function of inspired nitrous oxide concentration.
    Author: Fenwick PB, Stone SA, Bushman J, Enderby D.
    Journal: Electroencephalogr Clin Neurophysiol; 1984 Feb; 57(2):178-83. PubMed ID: 6198159.
    Abstract:
    The VEP to pattern displacement was measured at different levels of inspired N2O concentrations in air in 10 normal subjects. The inspired concentrations were 10, 20, 30 and 40% N2O. Expired CO2 concentrations were also measured. Ten normal controls went through the same procedure but breathed air on each trial rather than N2O. The results showed a significant decrease at 10%, almost at 20% and again significant at 30% and 40% for the amplitude of the N65-P95 wave. The P95-N125 wave was more resistant--10% was not significant, 20% was again nearly significant and 30% and 40% were significant. There were no latency changes. Because of the wider variance between group comparisons there was a significant reduction at 40% only for the N65-P95 wave and no significant difference for the P95-N125 wave. There was some evidence that the amplitude of the early components was still significantly reduced after the end of the experiment.
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