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  • Title: Hypomyelination in the cerebrum of the congenitally hypothyroid mouse (hyt).
    Author: Noguchi T, Sugisaki T.
    Journal: J Neurochem; 1984 Mar; 42(3):891-3. PubMed ID: 6198475.
    Abstract:
    2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the inherited primary hypothyroid mouse (hyt/hyt) is reduced in comparison with the normal heterozygate (hyt/+). No differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the hypothyroid mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.
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