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  • Title: Cell-free synthesis of factor VIII related protein.
    Author: Chan V, Chan TK.
    Journal: Thromb Haemost; 1983 Dec 30; 50(4):835-7. PubMed ID: 6198745.
    Abstract:
    Polyadenylated ribonucleic acid (RNA) was isolated from confluent human endothelial cells in culture and translated in a cell-free rabbit reticulocyte lysate protein-synthesizing system. Using specific immunoprecipitation, the translation product was found to contain 1.58% VIII related protein (VIII R), which has a molecular weight of 0.26 X 10(6), similar to the subunit of VIII R present in normal plasma. This indicated that VIII R messenger RNA is responsible for the synthesis of subunits only and intracellular post-translational events are required for the assembly of tetramer and multimers.
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