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  • Title: In vitro antibacterial activity of gramicidin and tyrothricin.
    Author: Ruckdeschel G, Beaufort F, Nahler G, Belzer O.
    Journal: Arzneimittelforschung; 1983; 33(12):1620-2. PubMed ID: 6199032.
    Abstract:
    815 recent clinical isolates of different species representing pathogenic or saprophytic constituents of human microbial flora were submitted to agar dilution tests. In concentrations above 64 micrograms/ml tyrothricin is in general equally as gramicidin or slightly more effective whereas below 8 micrograms/ml gramicidin is mostly more effective than tyrothricin. Of 401 streptococci all were inhibited by tyrothricin and gramicidin in concentrations up to 96 micrograms/ml; staphylococci were more resistant. The pathogenic species of 130 strains of gram-negative cocci were more susceptible than the saprophytic species. Haemophilus strains were mostly resistant to gramicidin and to a lesser extent to tyrothricin. Enterobacteriaceae were totally resistant to both antibiotics.
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