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  • Title: Allospecific suppression without requirement for participation of Ly 2+ cells.
    Author: Holán V, Mitchison NA.
    Journal: Immunology; 1984 Mar; 51(3):469-75. PubMed ID: 6199292.
    Abstract:
    Haplotype-specific suppressor T cells (Ts) were induced by incubation of mouse spleen/lymph node cells with allogeneic heat-treated cells. These Ts have an Ly 1+2- phenotype, and can be activated in cultures depleted of Ly 2+ cells by treatment with anti-Ly 2 antibodies and complement. In addition, these Ts inhibit alloantigen-induced proliferation of Ly 1+2- cells without the participation of Ly 2+ cells. These results show that allospecific suppressor T cells can be activated and can act without participation of Ly 2+, thus demonstrating that Ly 1+2- cells can directly suppress proliferation of other Ly 1+2- cells.
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