These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: In vivo and in vitro binding of alpha- and gamma-hexachlorocyclohexane to mouse liver macromolecules.
    Author: Iverson F, Ryan JJ, Lizotte R, Hierlihy SL.
    Journal: Toxicol Lett; 1984 Mar; 20(3):331-5. PubMed ID: 6199873.
    Abstract:
    alpha-Hexachlorocyclohexane (alpha-HCH) but not gamma-HCH, produces a strong neoplastic response in HPB strain mouse liver. In vivo and in vitro binding studies with 14C-labelled HCH isomers showed no preferential binding of the alpha-HCH isomer to protein or DNA. Moreover, the binding of both isomers to DNA in vivo or in vitro occurred only at very low levels, a result consistent with the lack of mutagenic activity associated with these compounds. The results suggest that the neoplastic response observed with alpha-HCH results from a non-genotoxic mechanism.
    [Abstract] [Full Text] [Related] [New Search]