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  • Title: Hepatic microsomal p-nitroanisole O-demethylase. Effects of chlordecone or mirex induction in male and female rats.
    Author: Ebel RE.
    Journal: Biochem Pharmacol; 1984 Feb 15; 33(4):559-64. PubMed ID: 6200121.
    Abstract:
    The effects of chlordecone (CD) or mirex treatment on the hepatic microsomal monooxygenase system of male and female rats were investigated, and kinetic parameters (apparent Vmax and apparent Km) for p-nitroanisole O-demethylase were studied in detail. Both pesticides elevated the levels of cytochrome P-450 in a time- and dose-dependent manner. The maximum rate of p-nitroanisole metabolism in males was increased about 100 and 50% and the apparent Km was elevated about 40- and 18-fold by CD and mirex respectively. p-Nitroanisole metabolism in females was reduced slightly by treatment with either agent, and the apparent Km was increased about 14-fold by CD but was relatively unaffected by mirex treatment.
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