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  • Title: Parallel secretion of endogenous 5-hydroxytryptamine and histamine from mast cells stimulated by vasoactive peptides and compound 48/80.
    Author: Carraway RE, Cochrane DE, Granier C, Kitabgi P, Leeman E, Singer EA.
    Journal: Br J Pharmacol; 1984 Feb; 81(2):227-9. PubMed ID: 6200170.
    Abstract:
    The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5-HT and histamine. Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5-HT.
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