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  • Title: [Effect of kontrikal on the kinin system of the lymph and blood in anaphylactic shock].
    Author: Minnebaev MM, Mukhutdinova FI, Musin MS.
    Journal: Farmakol Toksikol; 1984; 47(1):77-81. PubMed ID: 6200359.
    Abstract:
    A study was made of the effect of contrykal, a nonspecific inhibitor of the trypsin-plasmin-kallikrein system on the time course of kininogens and free kinins in the lymph of the thoracic duct and blood. Experiments were performed on 42 guinea-pigs with anaphylactic shock. It was demonstrated that anaphylactic shock was accompanied by the activation of the blood and lymph kinin system, manifesting in a decrease in the bradykininogen level and a rise in the content of free kinins in both body fluids. Pretreatment with contrykal did not avert the development of anaphylactic shock but significantly reduced the pronounced manifestations of the clinical picture and exerted an inhibitory action on the activation of the kallikrein-kinin system of the blood and lymph.
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