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  • Title: Initial studies of hypoxic radioprotection by deoxygenated dextran-hemoglobin.
    Author: Hill RP, Porter LS, Ives SA, Wong JT.
    Journal: Int J Radiat Oncol Biol Phys; 1984 Mar; 10(3):369-73. PubMed ID: 6200464.
    Abstract:
    Initial studies were performed to examine the potential of perfused dextran-hemoglobin to protect pig skin or mouse bone marrow cells against radiation damage. Some protection was indicated in both systems. In the pig skin a protection factor of 1.5 was observed for moist desquamation, and 2.0 for necrosis. These results suggest the possibility of using blood substitutes to induce tissue hypoxia for therapeutic purposes.
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