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  • Title: Indication of a possible role in a demyelinating neuropathy for an antigen shared between myelin and NK cells.
    Author: Murray N, Steck AJ.
    Journal: Lancet; 1984 Mar 31; 1(8379):711-3. PubMed ID: 6200739.
    Abstract:
    In three patients with monoclonal IgM antibodies to myelin-associated glycoprotein and a demyelinating neuropathy, the human monoclonal antibodies and HNK1, a mouse monoclonal antibody against human natural killer cells, reacted with the same region of myelin-associated glycoprotein. In these three patients there was a pronounced decrease in the number of circulating HNK1-positive cells. Taken together, these findings provide evidence that a cross-reactive cell surface antigen may be involved in an autoimmune response directed simultaneously against the nervous system and the immune system.
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