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  • Title: Substance K: a novel mammalian tachykinin that differs from substance P in its pharmacological profile.
    Author: Nawa H, Doteuchi M, Igano K, Inouye K, Nakanishi S.
    Journal: Life Sci; 1984 Mar 19; 34(12):1153-60. PubMed ID: 6200746.
    Abstract:
    The primary structure of one of the bovine brain substance P precursors has shown the existence of a second mammalian tachykinin sequence, named substance K, that is remarkably homologous to that of the amphibian peptide kassinin. In this study, three substance K sequences were chemically synthesized and were submitted to parallel bioassays with kassinin, substance P and physalaemin. The results show that the three substance K peptides all possess biological activities characteristic of the tachykinin family and that their biological activities more closely resemble those of kassinin than those of substance P or physalaemin. This suggests that substance K may have a physiological role which is related to but different from that of substance P in mammalian organisms.
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