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  • Title: Reversal of guanethidine blockade of sympathetic nerve terminals by tetraethylammonium and 4-aminopyridine.
    Author: Kirpekar M, Kirpekar SM, Prat JC.
    Journal: Br J Pharmacol; 1978 Jan; 62(1):75-8. PubMed ID: 620099.
    Abstract:
    1 The effect of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) on the inhibitory effect of guanethidine on noradrenaline (NA) release was investigated in the perfused spleen of the cat. 2 Guanethidine blocked the release of NA evoked by nerve stimulation. TEA and 4-AP readily reversed this inhibitory effect, and the NA output was nearly doubled after repeated stimulation of the nerves. On subsequent perfusion with Krebs solution without TEA or 4-AP, the inhibitory effect of guanethidine reappeared. 3 The reversal of guanethidine blockade of sympathetic nerves by TEA and 4-AP is discussed.
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