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  • Title: Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.
    Author: Rehn TG, Inman JK, Shearer GM.
    Journal: J Exp Med; 1976 Oct 01; 144(4):1134-40. PubMed ID: 62013.
    Abstract:
    The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.
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