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  • Title: Prevention by a carbacyclin analogue (ZK 36 374) of digoxin-induced ventricular extrasystoles in guinea-pig myocardium.
    Author: Metin M, Dörtlemez O, Dörtlemez H, Akar F, Ercan ZS, Türker RK.
    Journal: Eur J Pharmacol; 1984 Feb 10; 98(1):125-8. PubMed ID: 6201368.
    Abstract:
    Intravenous infusion of ZK 36 374 to the anesthetized guinea-pig or addition of the compound to the perfusion medium of the isolated perfused guinea-pig heart prevented digoxin-induced ventricular premature beats without altering the prolongation of the P-R interval by the glycoside. The prevention by ZK 36 374 of the ventricular extrasystoles induced by digoxin was obtained at lower concentrations while higher doses of the compound produced a dysrhythmic effect which terminated within a few min after the cessation of drug application.
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