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  • Title: [An animal model of hyperdynamic septic shock: hemodynamic effects of injection of low doses of endotoxin in the dog].
    Author: D'Orio V, Fossion A, Ferir A, Juchmès J, Marcelle R, Limet R.
    Journal: Arch Int Physiol Biochim; 1983 Nov; 91(4):261-7. PubMed ID: 6202257.
    Abstract:
    In anaesthetized dogs, low dose endotoxin perfusion (250 ng kg-1 min-1 during 20 min) resulted, after a delay of 15-40 min, in a decrease of mean arterial pressure (from 127 to 106 mm Hg), a transient increase in cardiac output (from 2.2 to 2.9 L/min), a fall of systemic vascular resistance (from 60 to 41 mm Hg L-1 min-1) and an increase in heart rate (from 109 to 156/min). This haemodynamic pattern is similar to the so called "hyperdynamic" initial phase of clinical septic shock.
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