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  • Title: [Inhibition, by an amphiphilic substance, niflumic acid, of the inward rectification of the crustacean muscle fiber].
    Author: Brûlé G, Haudecoeur G, Jdâïaa H, Guilbault P.
    Journal: Arch Int Physiol Biochim; 1983 Nov; 91(4):269-77. PubMed ID: 6202258.
    Abstract:
    Agents such as TEA+ or CS+ ions, these last ions instead of K+ ions in poor K extracellular solution, known to reduce or abolish the inwardly rectifying channel in many preparations produced no effect in crayfish muscle membrane By contrast, poor Cl extracellular solution (Cl- ions were replaced by CH3OSO3- ions) blocked the inward current activated by hyperpolarizing pulses and produced an increase of the resting potential. Niflumic acid is a agent which inhibited the inward going rectification of the crayfish muscle membrane. Apparent dissociation constant of niflumic acid with membrane sites was equal to about 6 X 10(-8) M; this value corresponds to that given by Cousin & Motais (1979) concerning translocation of Cl- ions in the membrane of red cells. Activation of the inward going rectification in the crayfish membrane is responsible of an inward current carried by Cl- ions.
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