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  • Title: Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.
    Author: de Pont JJ, Fleuren-Jakobs AM.
    Journal: FEBS Lett; 1984 May 07; 170(1):64-8. PubMed ID: 6202551.
    Abstract:
    The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.
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