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  • Title: Is somatostatin a true local inhibitory regulator of insulin secretion?
    Author: Kanatsuka A, Makino H, Osegawa M, Kasanuki J, Suzuki T, Yoshida S, Horie H.
    Journal: Diabetes; 1984 Jun; 33(6):510-5. PubMed ID: 6202577.
    Abstract:
    Pancreatic somatostatin was depleted after oral administration of cysteamine to rats, yet the B-cells in the isolated islets were morphologically and functionally intact. Compared with islets from the rats not given cysteamine, the somatostatin-depleted islets released larger amounts of insulin during 1 h of incubation by glucose or 3-isobutyl-1-methylxanthine stimulation. Therefore, the possibility that pancreatic somatostatin may locally regulate the inhibitory effects of insulin secretion has to be considered.
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