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  • Title: Neuronally mediated non-cholinergic contraction of guinea-pig bronchial smooth muscle is inhibited by a substance P antagonist.
    Author: Leander S, Grundström N, Andersson RG, Håkanson R.
    Journal: Agents Actions; 1984 Apr; 14(3-4):315-8. PubMed ID: 6203347.
    Abstract:
    The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (D-Pro2, D- Trp7 ,9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.
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