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  • Title: Evidence for a common protective antigenic determinant on sporozoites of several Theileria parva strains.
    Author: Musoke AJ, Nantulya VM, Rurangirwa FR, Buscher G.
    Journal: Immunology; 1984 Jun; 52(2):231-8. PubMed ID: 6203832.
    Abstract:
    The antigenic relationship amongst sporozoites of several Theileria parva strans isolated from different parts of East Africa was investigated. It was found that antibodies to T. parva ( Muguga ) sporozoites neutralized the infectivity of homologous sporozoites as well as those of T. parva (Uganda), T. parva lawrencei , T. parva ( Kiambu 5), T. parva ( Kabete 1) and T. parva ( Marikebuni ). The results correlated with those obtained from an in vivo challenge, in that cattle immunized against T. parva ( Muguga ) were either solidly resistant or developed only a transient parasitosis when challenged with T. parva lawrencei or T. parva (Uganda). The immunity exhibited by these animals paralleled the level of anti-sporozoite antibodies, such that animas with high titres were completely protected whereas those with low levels developed transient parasitosis. Furthermore, monoclonal antibodies made against sporozoites of T. parva ( Muguga ) were also capable of neutralizing the infectivity of sporozoites of other strains. These results indicate that the outcome of cross-challenge may depend on the level and avidity of the anti-sporozoite antibodies at the time of challenge. In addition, these findings show that there is a common protective antigenic determinant on sporozoites of all the T. parva strains investigated in this study.
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