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  • Title: Function of anti-Streptococcus mutans antibodies: anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity.
    Author: Gregory RL, Michalek SM, Shechmeister IL, McGhee JR.
    Journal: Infect Immun; 1984 Jul; 45(1):286-9. PubMed ID: 6203840.
    Abstract:
    Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by greater than 60%, acid production from sucrose by greater than 95%, and growth of the homologous S. mutans by greater than 59%. Inhibition of growth and acid production by immune sera and saliva were abrogated by prior adsorption with S. mutans 6715 whole cells, glucosyltransferase, lipoteichoic acid, or alpha 1-6 or alpha 1-3 dextran. These results indicate that antibodies induced to an S. mutans ribosomal preparation react with cell surface determinants and suggest that the antibodies inhibit sucrose-induced acid formation and growth of virulent S. mutans by neutralizing the glucose-phosphotransferase system.
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