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  • Title: Alpha 1-microglobulin in urine as an indicator of renal tubular damage caused by environmental cadmium exposure.
    Author: Nogawa K, Kido T, Yamada Y, Tsuritani I, Honda R, Ishizaki M, Terahata K.
    Journal: Toxicol Lett; 1984 Jul; 22(1):63-8. PubMed ID: 6205474.
    Abstract:
    Alpha1-Microglobulin (alpha 1-m) was determined in the urine of both the cadmium-exposed and nonexposed subjects and was compared with those of other urinary parameters such as beta 2-microglobulin (beta 2-m), glucose, total protein or amino acids. Large amounts of alpha 1-m were detected in the urine of cadmium-exposed subjects. There were significant correlations between alpha 1-m and other urinary parameters. The sensitivity and specificity of both alpha 1-m and beta 2-m as indices of tubular dysfunction caused by cadmium was similar. It was concluded that alpha 1-m in urine seemed to be a useful indicator of renal tubular dysfunction caused by cadmium.
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