These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Granulocytotoxic antibodies in a patient with propylthiouracil-induced agranulocytosis.
    Author: Guffy MM, Goeken NE, Burns CP.
    Journal: Arch Intern Med; 1984 Aug; 144(8):1687-8. PubMed ID: 6205633.
    Abstract:
    Agranulocytosis developed in a patient who was receiving propylthiouracil. Using a microgranulocytotoxicity assay, serum taken from the patient was shown to be strongly granulocytotoxic when tested against the patients granulocytes and those obtained from two of eight normal subjects. Tests for granulocyte agglutinins and for lymphocytotoxicity were negative. Granulocytotoxic activity decreased as the patient's peripheral granulocyte count recovered. Cytotoxicity was shown to be mediated by a complement-dependent IgM antibody.
    [Abstract] [Full Text] [Related] [New Search]