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  • Title: Monoclonal antibodies to polymorphic epitopes on Ia antigens: three independent groups of determinants expressed on DRw6 homozygous cells.
    Author: Johnson JP, Wank R.
    Journal: Eur J Immunol; 1984 Aug; 14(8):739-44. PubMed ID: 6205884.
    Abstract:
    Murine monoclonal antibodies directed against polymorphic epitopes on HLA-linked antigens were readily obtained following a single immunization with DRw6-homozygous cells. Five antibodies directed against class II antigens were isolated. Two precipitated DC-like molecules and 3 DR-like molecules from the immunizing lymphoblastoid cell line. Analysis of association with HLA-DR antigens in a panel of 60 individuals revealed 2 antibodies directed against the DC1 specificity (S1, R1) and one against the MT2 specificity (R3). Antibodies S2 and S3 showed significant association with DRw6 (chi 2 = 30.27) and DRw6 and w8 (chi 2 = 18.86), respectively. An analysis of 29 haplotypes indicated that epitopes defined by these monoclonal antibodies appear to identify polymorphic determinants on three independent gene products which can be encoded by a single HLA haplotype.
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