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  • Title: Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody.
    Author: Mathews MB, Reichlin M, Hughes GR, Bernstein RM.
    Journal: J Exp Med; 1984 Aug 01; 160(2):420-34. PubMed ID: 6206177.
    Abstract:
    An autoantibody known as PL-7 was found in the serum of four patients with myositis and one with a systemic lupus erythematosus-like syndrome. The PL-7 antigen is an 80,000 dalton polypeptide that coprecipitates with transfer RNA. In aminoacylation reactions, PL-7 IgG inhibited the charging of tRNA with threonine but had little or no effect on charging with other amino acids. Experimental antibodies raised against purified threonyl-tRNA synthetase recognized the same 80,000 dalton polypeptide, but tRNA was not coprecipitated. We conclude that PL-7 antibody is directed at threonyl-tRNA synthetase, and that different antigenic sites are recognized by the human and experimental autoantibodies. Our findings emphasize the link between myositis and autoimmunity to tRNA-related structures.
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