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  • Title: O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant.
    Author: Cheresh DA, Reisfeld RA, Varki AP.
    Journal: Science; 1984 Aug 24; 225(4664):844-6. PubMed ID: 6206564.
    Abstract:
    Monoclonal antibody Mab D1.1 recognizes on human melanoma cells a ganglioside antigen characterized by an alkali-labile O-acetylated sialic acid residue. Immunochemical analysis showed that this molecule is an O-acetylated product of the neuroectoderm-associated disialoganglioside GD3. Controlled chemical O-acetylation of purified GD3 resulted in the generation of this same epitope. Lysates of human melanoma cells were found to contain O-acetyltransferase activity capable of generating the antigenic epitope recognized by Mab D1.1. Thus, the addition of a single O-acetyl group to a common cell surface-associated ganglioside can create a potentially tumor-specific antigen.
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