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  • Title: [Cholestasis after antiarrhythmic therapy with propafenone].
    Author: Konz KH, Berg PA, Seipel L.
    Journal: Dtsch Med Wochenschr; 1984 Oct 05; 109(40):1525-7. PubMed ID: 6206993.
    Abstract:
    Propafenone, three times 150 mg/d over 33 days and two years later at the same dosage over six days, was administered to an 84-year-old man with ventricular extrasystoles (Lown IVa). Both times intrahepatic biliary stasis occurred, presumably a sign of a drug-allergic hepatitis. All other possible causes in the differential diagnosis were excluded. The lymphocyte transformation test demonstrated in vitro propafenone-sensitive patient-lymphocytes.
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