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  • Title: Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies.
    Author: Dale JB, Beachey EH.
    Journal: Infect Immun; 1984 Oct; 46(1):267-9. PubMed ID: 6207110.
    Abstract:
    A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially "rheumatogenic" serotypes.
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