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  • Title: Distribution and stability of [111In]bleomycin and its fractions in tumor-bearing mice.
    Author: Hou DY, Hoch H, Johnston GS, Tsou KC, Farkas RJ, Miller EE.
    Journal: Int J Nucl Med Biol; 1984; 11(2):129-39. PubMed ID: 6207129.
    Abstract:
    The tissue distributions in glioma-bearing mice given injections of [111In]bleomycin (BLM) indicated that tumor concentrations and ratios of tumor to blood, muscle and brain for [111In]BLM-B2 and -A2 were higher than those for unfractionated [111In]BLM. Autoradiographs of electrophoretic gels of urine containing [111In]BLM or one of its fractions differed from those containing 111InCl3. [111In]BLM and its fractions (A2 and B2) were found to be stable in vivo. The fractions may be more useful in the clinic than [111In]BLM.
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