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  • Title: Preservative activity in diluted corticosteroid creams.
    Author: Hugo WB, Denyer SP, York HL, Tucker JD.
    Journal: J Hosp Infect; 1984 Sep; 5(3):329-33. PubMed ID: 6208253.
    Abstract:
    The preservative efficacy of both 'Betnovate' and 'Synalar' creams diluted 1:1 with 'Unguentum Merck' was investigated. Each formulation was challenged with Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa at an initial inoculum level of approximately 1 X 10(6) viable organisms per gram of cream. All formulations tested were found to be effectively preserved against the organisms used and no viable bacteria were detected 7 days after inoculation.
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