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  • Title: Calcium entry activators: distinct sites of dihydropyridine and aminopyridine action.
    Author: Greenberg DA, Cooper EC, Carpenter CL.
    Journal: Neurosci Lett; 1984 Sep 07; 50(1-3):279-82. PubMed ID: 6208517.
    Abstract:
    The dihydropyridine compound BAY K 8644, a putative calcium entry activator, inhibits binding of the dihydropyridine calcium entry blocker, [3H]nitrendipine, to rat skeletal muscle membranes. In contrast, aminopyridine compounds also believed to stimulate calcium flux do not interact with [3H]nitrendipine binding sites in skeletal muscle or brain. These findings suggest that calcium entry activators, like calcium entry blockers, affect voltage-dependent calcium channels by diverse mechanisms.
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