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  • Title: [Lorcainide in stable ventricular extrasystole. A double-blind study with 48-hour continuous ECG recording].
    Author: Buss J, Stegaru B, Geiger S, Gores D, Heene DL.
    Journal: Dtsch Med Wochenschr; 1984 Nov 30; 109(48):1829-32. PubMed ID: 6209080.
    Abstract:
    In a randomized double-blind cross-over trial, the effectiveness of lorcainide at a dosage of three times 100 mg/d by mouth was compared with that of a placebo for the treatment of subjectively disturbing stable ventricular extrasystoles (VES), using 48-hour continuous ECG monitoring. In 11 of 20 patients there was a regression in the VES rate to under 5%, in other 3 patients to under 50% of the initial values. Continuing the treatment, good therapeutic effect was still demonstrable 14 and 28 days later. However, only three patients had no side-effects. The others had sleep disturbances, hot flushes, sweating, restlessness, anxiety, dizziness, hallucinations and gastrointestinal symptoms. Lorcainide thus has a good anti-arrhythmic effect but, because of its side-effects, it should be used only in special circumstances.
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