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  • Title: [Relation between the attachment of cells to a substrate and their proliferative characteristics].
    Author: Bershadskiĭ AD, Brodskaia RM, Mansurov PG, Stavrovskaia AA, Stromskaia TP.
    Journal: Eksp Onkol; 1984; 6(1):27-32. PubMed ID: 6209087.
    Abstract:
    17 cloned cell lines of transformed mouse fibroblasts were used for the evaluation of a correlation between three traits of malignancy: cloning efficiency in semisolid medium (CE); cell dose inducing tumours in 50% of inoculated animals (TD50); degree of cell attachment to a substrate (RT50--rounding time for 50% of the cells under moderate cooling, 18 degrees C). It is shown that an increase in RT50 (better attachment of the cells to the substrate) is accompanied by a decrease in CE and an increase in TD50 (coefficients of rank correlation p = -0.76 and p = 0.58, respectively). A negative correlation between CE and TD50 was also revealed (p = -0.68). A certain increase in the percentage of cells containing actin filament bundles was found in cell clones better attached to the substrate. Mechanisms of disturbances in proliferation and attachment of malignant cells are discussed.
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