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  • Title: Studies of anti-F(ab')2 antibodies and possible immunologic control mechanisms in systemic lupus erythematosus.
    Author: Silvestris F, Bankhurst AD, Searles RP, Williams RC.
    Journal: Arthritis Rheum; 1984 Dec; 27(12):1387-96. PubMed ID: 6210096.
    Abstract:
    Studies of anti-DNA and anti-F(ab')2 antibodies were performed by enzyme-linked immunosorbent assay in 51 patients with systemic lupus erythematosus (SLE). Patients with severe, uncontrolled disease showed high levels of anti-DNA and low levels of anti-F(ab')2 antibodies. Patients with quiescent SLE usually showed high levels of anti-F(ab')2 and low levels of anti-DNA antibodies. Isolated anti-F(ab')2 antibodies from autologous SLE remission serum or from the sera of unaffected siblings of SLE patients showed maximum inhibition in test systems using affinity-purified SLE anti-DNA antibodies reacting with single-stranded DNA.
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