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  • Title: [Pharmacological studies of FUT-175, nafamstat mesilate. II. Effects on experimental acute pancreatitis].
    Author: Iwaki M, Ozeki M, Sato T, Suzuki K, Motoyoshi A, Suzuki S, Fujita M, Aoyama T.
    Journal: Nihon Yakurigaku Zasshi; 1984 Oct; 84(4):363-72. PubMed ID: 6210233.
    Abstract:
    Effects of FUT-175, a novel synthetic protease-inhibiting agent, on various models of experimental acute pancreatitis were examined. FUT-175 infused i.v. at a dose range of 5-50 micrograms/kg/min inhibited the increase in plasma trypsin activity and reduced the mortality of rabbits in trypsin-induced acute pancreatitis in a dose-dependent manner. Increase in serum amylase activity and pancreatic tissue lesion were attenuated in rabbits. In addition, FUT-175 infused i.v. at a dose range of 1-50 micrograms/kg/min reduced the mortality of rats in experimental acute pancreatitis produced by trypsin and endotoxin. FUT-175 infused i.v. at a dose range of 1-100 micrograms/kg/min protected the dogs from the increase in plasma trypsin activity and hypotension and shock induced by trypsin, well-known characteristics of acute pancreatitis. These results suggest that FUT-175 is beneficial as a therapeutic agent of acute pancreatitis.
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