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  • Title: In vitro cellular effects of hematoporphyrin derivative.
    Author: Berns MW, Dahlman A, Johnson FM, Burns R, Sperling D, Guiltinan M, Siemens A, Walter R, Wright W, Hammer-Wilson M, Wile A.
    Journal: Cancer Res; 1982 Jun; 42(6):2325-9. PubMed ID: 6210430.
    Abstract:
    Several in vitro cell systems were exposed to hematoporphyrin derivative (HPD): established lines of rat kangaroo epithelial kidney; normal mouse embryonic fibroblasts; and differentiated neonatal rat myocardial cells. The uptake of HPD (25 to 100 micrograms/ml) by individual cells occurred rapidly over a 2-hr period and leveled off by 24 hr. HPD was excreted from cells by 48 hr after exposure. However, a low level of HPD (above background) was maintained in cells for up to 4 days following cessation of exposure. Intracellular binding of HPD was to mitochondria as demonstrated by fluorescence microscopy. HPD was also shown to have a growth-inhibiting effect on rat kangaroo cells without added light. The growth effects on mouse cells were less marked.
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