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  • Title: Effect of African swine fever on lymphocyte mitogenesis.
    Author: Wardley RC.
    Journal: Immunology; 1982 May; 46(1):215-20. PubMed ID: 6210625.
    Abstract:
    The effect of African swine fever virus replication on T and B lymphocytes was studied by mitogen-driven assays. Live attenuated isolates caused a marked suppressive effect which was dose- and time-dependent. This effect appeared to be mediated through a monokine. Live virulent isolates enhanced lymphocyte mitogenesis in most cases, with increased [3H]-thymidine uptake by T cells and increased Ig secretion by B cells. Killed preparation had no effect. These results are discussed in the light of the allergic response and immunopathological lesions produced by African swine fever virus infections.
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