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  • Title: [The echocardiography in thalassemia major (author's transl)].
    Author: Musumeci S, Schiliro G, Romeo MA, Di Gregorio F, Russo G, Scibilia G.
    Journal: Pediatr Med Chir; 1981; 3(2-3):219-22. PubMed ID: 6211659.
    Abstract:
    Echocardiographic findings were studied in seventeen subjects with beta-Thalassemia major in order to see whether cardiac lesions caused by iron were related to the age and chelating therapy. The results demonstrate that the alterations of the heart can be early detected by echocardiography. In fact no patient with echocardiographic alterations showed clinical signs of cardiac dysfunction and only four patients showed E.C.G. alterations. Moreover the thickening of posterior wall and left ventricular diastolic diameter were related to iron overload, as demonstrated by urinary excretion after desferrioxamine. Since the patients regularly treated with desferrioxamine were few and younger aged it is not possible in this study to show the positive effect of desferrioxamine treatment in preventing cardiac lesions due to iron overload.
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