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  • Title: Rapid and sensitive gas chromatographic quantitation of morphine codeine and O6-acetylmorphine in illicit heroin using an electron capture detector.
    Author: Moore JM.
    Journal: J Chromatogr; 1978 Jan 11; 147():327-36. PubMed ID: 621252.
    Abstract:
    Morphine, codeine and O6-acetylmorphine are reacted with heptafluorobutyric anhydride, rendering them suitable for electron capture detection and quantitation. The fluorinated derivatives are extracted from an acetonitrile-sodium bicarbonate solution into light petroleum in a rapid one-step extraction procedure. The derivatives are chromatographed on a stationary phase of 3% OV-17 on Gas-Chrom Q. Morphine, codeine and O6-acetylmorphine can be readily quantitated in heroin at levels as low as 0.001%, 0.01% and 0.01% respectively. Reproducibility, linearity and recovery studies are described.
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