These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.
    Author: Kina T, Nishikawa S, Katsura Y.
    Journal: Immunology; 1982 Jul; 46(3):583-7. PubMed ID: 6212536.
    Abstract:
    The regulation of pokeweed-mitogen (PWM) induced polyclonal immunoglobulin (Ig) production by suppressor T cells was investigated in mice. Generation of Ig-producing cells in PWM-stimulated culture was helped by T cells and the helper activity was markedly augmented by X-irradiation, suggesting that the suppressor cells which may coexist in the helper source were abolished by X-irradiation. Present study also provided direct evidence for the involvement of suppressor cells in PWM-induced Ig production. Thus, suppressor cells could be induced by prestimulation of splenic T cells with high doses of PWM for 3-4 days. Both the precursor and effector suppressor T cells in this system were found to be Lyt 1- 2+. It was further shown that although the Lyt 1- 2+ subset could be directly stimulated by PWM to generate suppressor cells, the presence of Lyt 1+ 2- cells in the culture markedly enhanced the generation of Lyt 1- 2+ suppressor cells.
    [Abstract] [Full Text] [Related] [New Search]