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  • Title: Protective effect of nicotinamide on bracken fern induced carcinogenicity in rats.
    Author: Pamukcu AM, Milli U, Bryan GT.
    Journal: Nutr Cancer; 1981; 3(2):86-93. PubMed ID: 6213941.
    Abstract:
    Albino noninbred weanling male and female rats were fed a basic grain diet (Group 1), a basic diet supplemented with 0.5% nicotinamide (Group 2), a basic diet containing 33% bracken fern (BF) (Group 3), or a basic diet supplemented with 33% BF and 0.5% nicotinamide (Group 4) for 58 weeks. Dietary nicotinamide decreased the BF-induced incidence of both intestinal and bladder tumorigenesis by about 40%. The inhibitory effect of nicotinamide on the BF-induced intestinal and bladder tumors was significant at p less than 0.05 and p less than 0.01, respectively.
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