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  • Title: Defect in the generation of cytotoxic T cells in lepromatous leprosy.
    Author: Stach JL, Strobel M, Fumoux F, Bach JF.
    Journal: Clin Exp Immunol; 1982 Jun; 48(3):633-40. PubMed ID: 6214342.
    Abstract:
    Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.
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