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  • Title: [Cytotoxicity in acne vulgaris].
    Author: Vignale RA, Espasandín J, Lasalvia E, Borras A.
    Journal: Med Cutan Ibero Lat Am; 1982; 10(1):31-6. PubMed ID: 6214674.
    Abstract:
    Three cellular cytotoxic lymphocytary populations were studied in patients with different forms of inflammatory acne vulgaris: direct or spontaneous, antibodies dependent and phytohemagglutinine stimulated. To these was added "Propionibacterium acnes" from cultures of material extracted separately from comedones and pustules. The direct or spontaneous and antibodies dependent cytotoxicity were normal. The subpopulation responsible of the phytohemagglutinine stimulated cytotoxicity has shown a clear hyperactivity which was augmented by the addition of these bacteria. But this hyperactivity stimulation was selective for the "Propionibacterium acnes" from pustules and not for those from comedones. These findings could contribute to the knowledge of the immune cellular mechanisms in acne vulgaris inflammation provoked by these bacteria.
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