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  • Title: Disorders of regulatory T cells in patients with selective IgA deficiency and its relationship to associated autoimmune phenomena.
    Author: De la Concha EG, Subiza JL, Fontán G, Pascual-Salcedo D, Sequí J, Bootello A.
    Journal: Clin Exp Immunol; 1982 Aug; 49(2):410-8. PubMed ID: 6215200.
    Abstract:
    In vitro lymphocyte function of 13 patients with selective IgA deficiency was studied. IgG, IgA and IgM secretion by pokeweed mitogen-stimulated peripheral blood lymphocytes from normal donors and IgA deficient patients was measured by an enzyme-linked immunosorbent assay. Addition of concanavalin A or hydrocortisone and co-cultures of B and T cell enriched populations from patients and normal donors, allowed us to investigate B cell Ig production and T cell regulatory abnormalities. IgA production by these patients' B cells was either absent or very low, as compared to their total Ig production, even in the presence of optimal T cell help. Several T cell immunoregulatory abnormalities were seen in different patients. A moderate increase in suppressor activity selective for IgA production was observed in some, but does not appear to play a major role in the pathogenesis of the IgA deficiency. In others, with associated autoimmune phenomena, a decrease in suppressor T cell function was found.
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