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  • Title: Plant anticancer agents V: new bisindole alkaloids from Tabernaemontana johnstonii stem bark.
    Author: Kingston DG, Gerhart BB, Ionescu F, Mangino MM, Sami SM.
    Journal: J Pharm Sci; 1978 Feb; 67(2):249-51. PubMed ID: 621649.
    Abstract:
    The isolation and structure elucidation of the three new bisindole alkaloids, gabunamine, tabernamine, and 19,20-epoxyconoduramine, from Tabernaemontana johnstonii stem bark are described. The isolation of the seven known alkaloids, conodurine, conoduramine, gabunine, isovacangine, ibogamine, pericyclivine, and perivine, from the same source also is noted. The alkaloids gabunamine, gabunine, and tabernamine showed significant cytotoxicity against the P-388 cell culture system.
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