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  • Title: Strong association between IgA nephropathy and HLA-DR4 antigen.
    Author: Kashiwabara H, Shishido H, Tomura S, Tuchida H, Miyajima T.
    Journal: Kidney Int; 1982 Oct; 22(4):377-82. PubMed ID: 6217371.
    Abstract:
    Although the etiology and pathogenesis of IgA nephropathy is not fully understood, it has been classified as an immune-complex induced glomerulonephritis caused by an immunological mechanism. Forty-two patients with primary IgA nephropathy underwent tissue typing for HLA-A, B, and DR antigens by the standard method using a microlymphocytotoxicity test. There was no significant correlation between HLA-A and B antigens and this disease. However, the frequency of HLA-DR4 was 57.1% in the patients with normal renal function, 85.7% in those with decreased renal function, 100% in dialysis patients, and 39.2% in the control group. It is statistically significant in the patients with renal dysfunction (corrected P less than 0.05). Our results suggest that the HLA system may play an important role in the occurrence and exacerbation of IgA nephropathy in the Japanese population.
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